• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to the non-therapeutic use of a composition comprising at least one 1,4: 3,6 dianhydrohexitol for moisturizing the skin as well as a preparation for topical use comprising at least one 1,4: 3,6 dianhydrohexitol. as a moisturizing agent.
    公开号:FR3069775A1
    申请号:FR1757421
    申请日:2017-08-02
    公开日:2019-02-08
    发明作者:Daniel Wils；Leon Mentink
    申请人:Roquette Freres SA；
    IPC主号:
    专利说明:

    Field of the invention
    The subject of the invention is the non-therapeutic use of a composition based on 1.4: 3.6 dianhydrohexitol, preferably based on isosorbide, for moisturizing the skin.
    State of the art
    Today the most widely used skin moisturizer in the cosmetic field is glycerin. It is in fact contained in a large number of cosmetic products for topical use, such as creams, lotions, shower gels and shampoos, to give them moisturizing properties. However, glycerin has a number of sensory disadvantages when used in high amounts. Indeed, depending on the topical preparations selected, a glycerin content greater than 20%, or even greater than only 10% by weight relative to the weight of said preparation, results in a greasy and sticky feel on the skin, considered unpleasant.
    Patent application EP 1 891 929 A1 describes the use of isosorbide as an anti-wrinkle agent in cosmetic preparations for the skin such as creams or lotions. According to this request, isosorbide reduces the thickening of the epidermis induced by photoaging, which results in a reduction of wrinkles. A hydrating effect of isosorbide is neither described nor suggested.
    In view of the drawbacks of glycerin, one of the objectives of the present invention is to provide an alternative to glycerin which does not have these drawbacks of greasy and sticky feel.
    After intense research and tests using different products, in particular different polyols, the Applicant has found that this objective could be achieved by choosing a particular polyol having a high hydrating power without leaving a greasy or sticky feel on the skin.
    Summary of the invention
    Thus, the subject of the invention is the non-therapeutic use of a composition comprising at least one 1,4: 3,6 dianhydrohexitol, in particular isosorbide, for hydrating the skin as well as a composition for topical use comprising a composition comprising at least one 1,4: 3,6 dianhydrohexitol, this at least one 1,4: 3,6 dianhydrohexitol being in particular isosorbide, as hydrating agent.
    Detailed description of the invention
    Unexpectedly, 1: 4, 3: 6 dianhydrohexitols, including isosorbide, have been shown to be skin moisturizers with good hydrating power, both instantly and over time. Unlike glycerin, a preparation for topical use formulated with a composition comprising at least one 1,4: 3,6 dianhydrohexitol leaves a dry and powdery feel on the skin. Even when used in high amounts, i.e. above 10% or even above 20% by dry weight, a composition comprising at least one 1,4: 3,6 dianhydrohexitol does not give rise to a greasy and sticky touch. In addition, and very advantageously, it provides a greater feeling of freshness than glycerin. Furthermore, the Applicant has noted that a preparation for topical use formulated with a composition comprising at least one 1,4: 3,6 dianhydrohexitol spreads more easily on the skin and penetrates better into the skin than a control preparation formulated with glycerin.
    Throughout the present application, the hydrating power is similar to the capacity of a preparation for topical use to hydrate the surface layer of the epidermis: the water contained in said preparation will be conveyed in this layer. From a sensory point of view, this results in a feeling of freshness. This hydrating power can for example be measured by corneometry, a scientifically recognized method for measuring the hydration of the surface layers of the skin, the implementation of which is explained in more detail in the examples section.
    Hydrating power should not be confused with other properties that are measured on the surface of the skin and not in the layers of the epidermis. This is for example the case of touch. Certain characteristics of the touch do not depend on the hydrating power: thus, a preparation for topical use can cause a greasy and sticky feel if it is for example based on glycerin, or conversely dry and powdery as in the case of the invention. In some cases, touch can be influenced by the hydrating power: better hydration of the upper layer of the epidermis makes the skin softer and more elastic. But in all cases, touch refers to a property that is measured on the surface of the skin, not in the layers of the epidermis.
    When these properties are the subject of examples and characterizations in the present application, the related tests clearly establish the reference frame chosen: the surface layer of the epidermis for the hydrating power, and the surface of the epidermis for the touch. .
    1,4: 3,6 dianhydrohexitols, also called simply dianhydrohexitols or isohexides, are products of double internal dehydration of C6 polyols (hexitols) such as sorbitol, mannitol and iditol. In the present application, the term “1.4: 3.6 dianhydrohexitol” includes isosorbide (1.4: 3.6 dianhydrosorbitol), isomannide (1.4: 3.6 dianhydromannitol), isoidide (1.4: 3.6 dianhydroiditol). Also, the composition used in accordance with the invention may contain a single 1.4: 3.6 dianhydrohexitol, preferably isosorbide, or any mixture of the above 1.4: 3.6 dianhydrohexitols. The composition comprising at least one 1,4: 3,6 dianhydrohexitol used according to the invention can be used in solid form, preferably crystallized, in particular in the form of powder or of scales, or in liquid form. In the first case, in solid form, the composition is not necessarily completely anhydrous and can therefore contain water in small quantities, in particular up to about 5% by weight. In the second case, it is generally a paste or an aqueous solution of at least one 1,4: 3,6 dianhydrohexitol having a dry matter which may be between 1 and 95% by weight. Preferably, for reasons of logistic and storage costs but also for the ease of implementation during the production of the preparation for topical use, a concentrated solution of 1.4: 3.6 dianhydrohexitol, c ' that is to say having a dry matter greater than 30% by weight, preferably greater than 50% by weight and better still greater than 70% by weight. In particular, a composition of 1.4: 3.6 dianhydrohexitol having a dry matter of between 75% and 85% by weight may be used.
    The 1,4: 3,6 dianhydrohexitols being natural products resulting from the transformation of starch, they always contain impurities such as for example caramelized sugars and products resulting from thermal reactions or Maillard. This is why they are generally used in the form of a composition, the dry weight content of which consists essentially of a single 1.4: 3.6 dianhydrohexitol. For the purposes of the present invention, the term "dry weight content essentially consisting of at least one 1.4: 3.6 dianhydrohexitol" a 1.4: 3.6 dianhydrohexitol content of at least 75% dry / dry weight and preferably at least 90% dry / dry weight. Even if the degree of purity of the composition used in accordance with the invention or in other words its dry weight content of 1,4: 3,6 dianhydrohexitol relative to the total dry matter has not appeared per se of paramount importance with regard to its hydrating power of the skin, it is however preferable for organoleptic, sensory or security reasons, than its dry weight content of 1.4: 3.6 dianhydrohexitol relative to the total dry matter as high as possible. For this, a composition will be used, the dry weight content of which consists essentially of a 1,4: 3,6 dianhydrohexitol in the most purified form possible, in particular obtained following distillation or crystallization steps.
    Thus, the presence of coloring or odorous impurities such as, for example, caramelized sugars and products resulting from thermal or Maillard reactions which some of these compositions of 1.4: 3.6 dianhydrohexitol may not contain, will be limited to a content of dry weight less than 2%, better still less than 1% and even better still less than 0.5% relative to the total dry matter in 1.4: 3.6 dianhydrohexitol of the composition. Ideally, the presence of coloring or odorous impurities is less than 0.2% relative to this dry matter and preferably less than 0.1% relative to this dry matter. Even more preferably, the composition is colorless and is completely neutral in odor. Therefore, advantageously the composition used according to the invention will be prepared from or will comprise a composition whose dry weight content consists essentially of a single 1,4: 3,6 dianhydrohexitol, this dry weight content being at less than 98%, preferably at least 99% and more preferably at least 99.5%.
    As mentioned above, the composition used according to the invention can comprise several 1.4: 3.6 dianhydrohexitols or a single 1.4: 3.6 dianhydrohexitol, preferably isosorbide. This composition can be used alone or in admixture with other products which may be of interest for the formulation of the preparation for topical use, such as in particular other hydrating agents such as betaine, sorbitol, xylitol, glycerin. or acetamidoethoxyethanol or other active products or products with sensory effects on the skin, such as for example starch.
    In the context of the present invention, a composition is preferably used in which the at least one 1,4: 3,6 dianhydrohexitol is isosorbide. As indicated above, it can be used in solid or liquid form, preferably having an isosorbide content at least equal to 98.5% by dry weight, preferably at least equal to 99% by dry weight and more preferably still. at least equal to 99.5% by dry weight relative to the total dry matter. Preferably, isosorbide is used in liquid form. The range of isosorbide marketed by the applicant company under the trade name POLYSORB® is particularly suitable for the purposes of the present invention.
    According to one embodiment, the composition comprising at least one 1,4: 3,6 dianhydrohexitol, in particular the composition comprising isosorbide, is incorporated into a preparation for topical use. The term “preparation for topical use” within the meaning of the present invention means any composition intended to be brought into contact with the skin, human or animal. It can thus be a cosmetic composition, a pharmaceutical composition or a veterinary composition. Nonlimiting examples of preparations for topical use include lotions, creams, serums, gels, ointments, balms, liquid soaps or shower gels, shampoos, foams, foundations, antiperspirants and deodorants. These preparations may comprise, in addition to the composition comprising at least one 1,4: 3,6 dianhydrohexitol, of other ingredients usually used in preparations for topical use, such as for example cosmetic, pharmaceutical and / or veterinary active principles, and adjuvants such as preservatives, solubilizers or perfumes. It can also include other hydrating agents such as betaine, sorbitol, xylitol, glycerin or acetamidoethoxyethanol or other active products or products with sensory effects on the skin, such as for example starch.
    Thanks to its hydrating power and its good sensory properties, the composition comprising at least one 1,4: 3,6 dianhydrohexitol can be used as a replacement, total or partial, for the glycerin usually used as hydrating agent in preparations for topical use. Preferably, it completely replaces glycerine. In this case, the preparation for topical use is free of glycerin. Alternatively, the preparation for topical use may contain glycerin at a low content, in particular less than or equal to 10%, preferably less than or equal to 5% and more preferably still less than or equal to 1% by weight relative to the total weight. of preparation.
    The total content of 1.4: 3.6 dianhydrohexitol in the preparation for topical use may be between 0.1% and 50%, preferably between 1% and 40%, more preferably still between 5% and 30% and better still between 10% and 25% by dry weight relative to the total weight of the preparation. It is understood that the use of the term "1,4: 3,6 dianhydrohexitol" in the singular in the context of the content in the preparation for topical use means that it may be the content of a single 1 , 4: 3.6 dianhydrohexitol or in several 1.4: 3.6 dianhydrohexitols.
    The use of a composition comprising at least one 1,4: 3,6 dianhydrohexitol as hydrating agent has many advantages as explained above. In particular, the use of at least one 1,4: 3,6 dianhydrohexitol as hydrating agent has the advantage of not giving a greasy and / or sticky feel but dry and powdery even when used at high contents, in particular at total contents of 1,4: 3,6 dianhydrohexitol greater than or equal to 10% by dry weight relative to the total weight of the composition. Thus, the 1.4: 3.6 dianhydrohexitol content of the preparation for topical use is advantageously greater than or equal to 10%, preferably greater than or equal to 15%, more preferably still greater than or equal to 20% by dry weight relative to the total weight of the preparation. Advantageously, this content will not exceed 40%, preferably 30% and more preferably still 25% by dry weight relative to the total weight of the preparation.
    The invention also relates to a preparation for topical use comprising a hydrating agent, said hydrating agent being a composition comprising at least one 1,4: 3,6 dianhydrohexitol, as described above. As indicated above, this composition can in particular be free of glycerin.
    The invention also relates to a method of hydration of the skin comprising the application to the surface of the skin of a preparation for topical use as described above.
    Naturally, other embodiments of the invention could have been envisaged by a person skilled in the art without departing from the scope of the invention defined by the claims below.
    The invention will now be illustrated in the following non-limiting examples.
    Examples:
    Example 1:
    Different polyols have been incorporated into body milk as a preparation for topical use. 5 panelists evaluated touch on the skin after applying each of the formulas after spreading 0.2g of product on a surface of 1cmx5cm on the forearm, spreading by 10 rotations and a waiting time of 2 minutes.
    The composition of the lotion was as follows (% by weight / total weight):
    Phase INCI name Function % AT tocopherol antioxidant 0.02 Stearic acid & palmitic acid surfactant 5.00 Glyceryl stearate texturizing 5.50 Seed oil of helianthus annuus (sunflower) Emollient 10.00 B Aqua (water) Solvent 57.98 triethanolamine neutralizer 0.50 Phenoxyethanol & Chlorphenesine & Glycerin Conservative 1.00 Polyol (expressed as dry matter) moisturizer 20.00
    100.00
    Operating mode
    1 / With magnetic stirring, prepare mixtures A and B separately, heat to 70 ° C
    2 / Add A to B under a stator rotor for 2 minutes then pass the mixture under a deflocculator and with gentle stirring.
    The results of the tests are summarized in Table 1:
    Table 1
    polyol Touch on the skin Glycerin (99.9%) fat and sticky Xylitol (XYLISORB® 300) fat and sticky Sorbitol (NEOSORB® P650) fat and sticky Maltitol (SWEETPEARL®P200) fat and sticky Isosorbide (POLYSORB®LP marketed byApplicant (1)) non-greasy and non-sticky;dry and powdery
    (1): Appearance: uncoored transparent liquid and completely odorless - Dry matter: 80% - Purity: 99.5% minimum in isosorbide compared to dry matter
    - Impurities: less than 0.5% compared to the dry matter - pH in 40% aqueous solution of 7.5.
    These results clearly show that among the polyols tested, only isosorbide makes it possible to obtain body milk without a greasy or sticky feel. In addition, isosorbide gives the skin a very pleasant dry and powdery feel.
    Example 2:
    The hydrating effectiveness of isosorbide has been compared to that of sorbitol, xylitol, betaine and glycerin. For this, these polyols have been incorporated into a cosmetic preparation for topical use in the form of a gel.
    The composition of the gel was as follows (% by weight / total weight): 6% by weight of isososorbide, 15 sorbitol, xylitol, betaine or glycerin and 1% by weight of gelling carbomer in water. The placebo is made up of only 1% by weight of gelling carbomer in water.
    The hydrating efficacy of each of the preparations for topical use was evaluated by corneometry. Corneometry is a scientifically recognized method for measuring the hydration of the surface layers of the skin. It is based on the determination of the capacitance of the superficial stratum corneum.
    The study was carried out with ten healthy volunteers, aged 18 to 65 years. The hydrating effectiveness of each of the five formulas was evaluated 1 hour, 2 hours and 4 hours after its application in the laboratory on the inside of the forearm. The evaluation was carried out by comparing the hydration level of the area to which the product was applied after 1 hour (T1 h), 2 hours (T2h) and 4 hours (T4h) with the hydration level measured before product application (TO).
    For each formula an amount of approximately 2 mg / cm 2 was applied to an area of 3 x 3 cm, in non-occlusive epicutaneous mode. In addition to the areas treated with the five formulas, two additional areas were evaluated: one treated with a placebo and the other without treatment for the duration of the study.
    The measurements were carried out with a Corneometer® CM285 included in a Multiprobe Adapter System MPA® (Courage-Khazaka GmbH, Germany). The instrument determines the capacitance of the epidermis, which is proportional to its water content, at a depth of about 15 µm. This method is based on the difference between the electrical permittivity of water which is 81 and that of other substances (<7). The Corneometer probe (49 mm 2 surface ) is positioned perpendicular to the test area which has been previously delimited with a pencil. The capacitance measurement takes 1 second.
    Each measurement is performed twice and the average of the two measurements is noted.
    The instrument gives values in arbitrary units ranging from 0 to 130, with a margin of error of ± 3%.
    Each volunteer rested for about 1 minute in an air-conditioned room before each measurement with the Corneometer® to avoid abnormal results due to excessive sweating or stress.
    Table 2 below reports the average hydration values expressed in arbitrary units (AU). The variations in hydration between TO and T1 h, T2h and T4h respectively are given in Table 3.
    Table 2
    TIME sorbitol xylitol isosorbide betaine Glycerin Placebo Untreated TO 48.60 45.94 46.54 43.39 42.03 45.58 49.17 T1h 54.16 55.37 56.60 55.61 57.05 38.84 45.47 T2h 49,11 52.68 52.88 54,30 56.15 38,06 45.51 T4H 46.91 45.28 52.50 50.74 56.57 38.39 47.05
    Table 3
    TIME Average changes in% (1) sorbitol xylitol isosorbide betaine Glycerin Placebo Untreated T1h vs T0 11.4 20.5 21.6 28.2 35.7 -14.8 -7.5 T2h vs T0 1.0 14.7 13.6 25.1 33.6 -16.5 -7.4 T4h vs T0 -3.5 -1.4 12.8 16.9 34.6 -15.8 -4.3
    (1) T ... h-TO / TO * 100
    It is remarkable and surprising to note that all the polyols do not have the same effect both from the point of view of instant hydration (at short time, that is to say at 1 hour) and the maintenance of hydration over time (i.e. at 2 or 4 hours). Most polyols with the exception of isosorbide do not maintain skin hydration over time. Only isosorbide makes it possible to obtain a very good compromise between short-term hydration and maintenance of hydration over time (T4h vs T0). From this point of view, isosorbide gives the gel a satisfactory hydrating power, comparable to that of betaine.
    Example 3:
    A blind discriminative sensory analysis on two body milks as a preparation for topical use, one with isosorbide as a hydrating agent and the other with glycerin, was carried out with 37 panelists expert in sensory texture analysis.
    The compositions of the two body milks evaluated correspond to those given in Example 1.
    Test procedure
    The two body milks are offered in comparison and randomized for each panelist. 20 Two pairs of products are evaluated per session
    For each product, the panelist must evaluate the following descriptors on the surface of the epidermis: fresh, spreading, fatty, sticky, soft, penetration.
    Each panelist scores the descriptors on a scale between 0 and 10.
    Assessment protocol
    The forearms are washed beforehand. Then, two application areas with a surface area of 5cm 2 (1x5) are traced on the forearm of each panelist for the evaluation of the products.
    0.2 g of each product is applied to the demarcated area to be evaluated.
    The criteria for evaluating the descriptors linked to the spreading of the product are given in table 4 below and those linked to touch in tables 5 and 6 respectively.
    Table 4
    DESCRIPTOR GESTURE DEFINITION FRESH Examination after application of0.2g by the leading panel onforearm, doing 10rotations Until the 2nd rotation, the product provides a cooling sensation, comparable to fresh water on the skin. SPREADING From the 5th to the 10th rotation, the product does not oppose resistance to sprawl, and is distributed on homogeneous layer of the skin.
    Table 5
    DESCRIPTOR GESTURE DEFINITION GRAS Examination 1 minute laterapplication and spreading by10 rotations By pinching the skin between the thumb andthe index finger, we feel the presence of aproduct thickness. TIGHTS By tapping the skin with the index finger, aadhesion is felt: the product hinders themovement.
    Table 6
    DESCRIPTOR GESTURE DEFINITION PENETRATING Examination 2 minutes laterapplication and spreading by10 rotations By sliding on the skin,the product is gone and no residue isrecovered. SOFT By caressing the skin, the touch is dryand slippery, the skin is softer than atnatural.
    The average for each descriptor for each of the two body milks is given in Table 7.
    Table 7
    Isosorbide body milk 5Glycerin body milk Variables evaluated averages averages FRESH 4.85 4.4 SPREADING 7.7 7.45 GRAS 6.45 6.8 TIGHTS 2.85 3.45 SOFT 5.85 5.65 PENETRATING 7.95 7.7
    These results show that body milk containing isosorbide as a hydrating agent is significantly less sticky and fatty than body milk compared to glycerin. In addition, it spreads better, provides a greater feeling of freshness, is softer and more penetrating. In conclusion, the use of isosorbide as a total replacement for glycerin induces the sensory benefits sought by the consumer that glycerin is unable to provide.
    权利要求:
    Claims (15)
    [1" id="c-fr-0001]
    CLAIMS » 10 11 12
    1. Non-therapeutic use of a composition comprising at least one 1,4: 3,6 dianhydrohexitol for hydrating the skin.
    [2" id="c-fr-0002]
    2. Use according to claim 1, wherein the 1,4: 3,6 dianhydrohexitol is isosorbide.
    [3" id="c-fr-0003]
    3. Use according to one of the preceding claims, in which the composition comprising at least 1.4: 3.6 dianhydrohexitol is used in liquid form, preferably in a dry matter of between 75 and 85%.
    [4" id="c-fr-0004]
    4. Use according to claim 1 or 2, wherein in which the composition comprising at least one 1,4: 3,6 dianhydrohexitol is used in solid form, preferably crystallized, in particular in the form of powder or scales.
    [5" id="c-fr-0005]
    5. Use according to one of the preceding claims, in which the composition comprising at least one 1,4: 3,6 dianhydrohexitol is incorporated in a preparation for topical use.
    [6" id="c-fr-0006]
    6. Use according to one of the preceding claims, in which the preparation for topical use is a cosmetic preparation, a pharmaceutical preparation or a veterinary preparation.
    [7" id="c-fr-0007]
    7. Use according to claim 5 or 6, wherein the preparation for topical use is free of glycerin.
    [8" id="c-fr-0008]
    8. Use according to claim 5 or 6, in which the preparation for topical use has a glycerin content of less than or equal to 10%, preferably less than or equal to 5% and more preferably still less than or equal to 1% by weight. relative to the total weight of the preparation.
    [9" id="c-fr-0009]
    9. Use according to one of claims 1 to 8, in which the preparation for topical use has a 1.4: 3.6 dianhydrohexitol content of between 0.1% and 50%, preferably between 1% and 40% , more preferably still between 5% and 30% and better still between 10% and 25% by dry weight relative to the total weight of the preparation.
    [10" id="c-fr-0010]
    10. Preparation for topical use comprising a hydrating agent, characterized in that the hydrating agent is a composition comprising at least one 1,4: 3,6 dianhydrohexitol.
    [11" id="c-fr-0011]
    11. Preparation according to claim 10, in which at least one 1,4: 3,6 dianhydrohexitol is isosorbide.
    [12" id="c-fr-0012]
    12. Preparation according to claim 10 or 11, wherein the preparation is a cosmetic preparation, a pharmaceutical preparation or a veterinary preparation.
    [13" id="c-fr-0013]
    13., Preparation according to one of claims 10 to 12, free of glycerin.
    [14" id="c-fr-0014]
    14. Preparation according to one of claims 10 to 12, having a glycerine content of less than or equal to 10%, preferably less than or equal to 5% and more preferably still less than or equal to 1% by weight relative to the total weight of the
    5 preparation.
    [15" id="c-fr-0015]
    15. Preparation according to one of claims 10 to 14, having a content of 1.4: 3.6 dianhydrohexitol of between 0.1% and 50%, preferably between 1% and 40%, more preferably still between 5% and 30% and better still between 10% and 25% by dry weight relative to the total weight of the preparation.
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    同族专利:
    公开号 | 公开日
    CN110944621A|2020-03-31|
    EP3661483A1|2020-06-10|
    US20200230042A1|2020-07-23|
    FR3069775B1|2020-02-14|
    KR20200035032A|2020-04-01|
    CA3071546A1|2019-02-07|
    WO2019025730A1|2019-02-07|
    JP2020529417A|2020-10-08|
    BR112020001992A2|2020-08-18|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US20110117036A1|2009-11-13|2011-05-19|Sytheon Limited|Compositions and Methods for Improving Skin Appearance|
    US20130183257A1|2009-11-13|2013-07-18|Sytheon Ltd.|Compositions and methods for improving skin appearance|
    TWI312687B|2005-04-21|2009-08-01|Kao Corporatio|Skin lotion and wrinkle improving agent|EP3946235A1|2019-03-28|2022-02-09|Roquette Freres|Use of dianhydrohexitol to eliminate the cosmetic effects of acne, dandruff and bad odors|
    FR3094215B1|2019-03-28|2021-03-26|Roquette Freres|Using dianhydrohexitol to eliminate the cosmetic effects of acne|
    FR3094217A1|2019-03-28|2020-10-02|Roquette Freres|Use of dianhydrohexitol for the preservation of cosmetic preparations|
    法律状态:
    2019-02-08| PLSC| Search report ready|Effective date: 20190208 |
    2019-08-30| PLFP| Fee payment|Year of fee payment: 3 |
    2020-08-31| PLFP| Fee payment|Year of fee payment: 4 |
    2021-08-31| PLFP| Fee payment|Year of fee payment: 5 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1757421|2017-08-02|
    FR1757421A|FR3069775B1|2017-08-02|2017-08-02|1.4: 3.6 DIANHYDROHEXITOLS TO HYDRATE THE SKIN|FR1757421A| FR3069775B1|2017-08-02|2017-08-02|1.4: 3.6 DIANHYDROHEXITOLS TO HYDRATE THE SKIN|
    BR112020001992-5A| BR112020001992A2|2017-08-02|2018-08-01|1.4: 3.6 dianhydro-hexitols to hydrate the skin|
    JP2020505407A| JP2020529417A|2017-08-02|2018-08-01|1,4: 3,6-Dianhydrohexitols for moisturizing the skin|
    KR1020207002740A| KR20200035032A|2017-08-02|2018-08-01|1,4: 3,6-dianhydrohexitol for moisturizing skin|
    CA3071546A| CA3071546A1|2017-08-02|2018-08-01|1,4 :3,6 dianhydrohexitols for moisturising the skin|
    CN201880049408.4A| CN110944621A|2017-08-02|2018-08-01|1,4:3, 6-dianhydrohexitols for skin moisturization|
    EP18758949.4A| EP3661483A1|2017-08-02|2018-08-01|1,4: 3,6 dianhydrohexitols for moisturising the skin|
    US16/633,536| US20200230042A1|2017-08-02|2018-08-01|1,4: 3,6 dianhydrohexitols for moisturising the skin|
    PCT/FR2018/051981| WO2019025730A1|2017-08-02|2018-08-01|1,4: 3,6 dianhydrohexitols for moisturising the skin|
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